FEASIBILITY STUDY TO PRODUCE HETEROGENOUS IMMUNOGLOBULIN

THIS RESEARCH WILL DETERMINE THE FEASIBILITY OF PRODUCING IMMUNOGLOBULINS AGAINST THE OPPORTUNISTIC ENTERIC INFECTIONSOF HIV-INFECTED NEONATES UTILIZING THE COLOSTRUM FROM HYPERIMMUNIZED COWS OR THE EGG YOLK IMMUNOGLOBULINS AVAILABLE FROM HYPERIMMUNIZED CHICKENS. THESE TWO COMMON DOMESTIC ANIMALS WOULD BE IMMUNIZED WITH THE LABORATORY ISOLATES FROM A MEDICAL CENTER TREATING AIDS NEONATES. HETEROGENEOUS IMMUNOGLOBULINS WOULD BE INEXPENSIVE TO PRODUCE. AS THEY ARE POLYCLONAL, THEY COULD BE USED FOR MANY PATHOGENS AND COULD BE EFFECTIVE WHEN TAKEN ORALLY. THEY WOULD NOT POSE A TOXICITY PROBLEM, AS OCCURS WITH SOME PHARMACEUTICALS. FAVORABLE RESULTS OF THIS STUDY COULD OFFER PREVENTIVE METHODS FOR PATIENTS IN UNDERDEVELOPED COUNTRIES. THE IMMUNOGLOBULINS PRODUCED FROM THIS RESEARCH WOULD BE AVAILABLE TO ANY MEDICAL INSTITUTION WISHING TO DO CLINICAL TRIALS.