SBIR/STTR Research Award
DEVELOPMENT OF APTAMERS TO RECOGNIZE NOD-LIKE RECEPTORS IN ZEBRAFISH
Award amount
$600,000Program and phase
SBIR · Phase IAward year
2021Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- National Institutes of Health
- Recipient company
- Proteovista LLC
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- GYNUUKETC8F4
- Solicitation number
- PHS2021-1
- Topic code
- 94
Research abstract
The goal of this project is to develop aptameric detection reagents for six zebrafish NOD-like receptors (NLRs) that recognize PAMPs and DAMPs in innate immune cells. Aptamers are an attractive alternative to antibodies as a high affinity reagent for specific binding and detection of proteins due to their structural diversity and ease of synthesis. The success of this project will yield aptamers for detecting important NLR targets to examine immune responses in the zebrafish model for immunology and infectious disease studies.
Technology keywords
Not reported
Other awards by this recipient
Verified by the same UEI. These are other public SBIR/STTR award pages, not a merged company record.
- Development of GenomeBuild as a Universal Method to Synthesize Genomes
- Development of the High Throughput APT-SNAP Platform for Rapid Identification ofNuclease-Resistant RNA Aptamers against p53 Missense Mutations
- Site-Specific Incorporation of Phosphorylation Modifications on the SNAP-Tide High Density Peptide Array
- Aptamer-Based Detection of Cardiac Biomarker Glycosylation States Using APT-SNAP
- Screening of FoxA1-ER-DNA disruptors for development of breast cancer therapeutic
Research funding history
7 SBIR/STTR records share this UEI (2011–2023). Reported award amounts total $2,583,391. Reported amounts are not federal obligations.
Phases: Phase I
Agencies: Department of Health and Human Services