SBIR/STTR Research Award
Comprehensive Solution for Transcriptome Profiling of Archived Tissues
Award amount
$225,000Program and phase
SBIR · Phase IAward year
2014Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- National Institutes of Health
- Recipient company
- ASURAGEN, INC.
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- E8M9NXN4X4Y7
- Solicitation number
- ES13-009
- Topic code
- NIEHS
Research abstract
DESCRIPTION (provided by applicant): The overall goal of this proposal is to expand the capability for molecular analyses of formalin fixed paraffin-embedded (FFPE) specimens through the use of whole transcriptome profiling with next generation sequencingtechnology (RNA-Seq). An end-to-end strategy will be developed that includes both experimental and analytical methods to address challenges specific to FFPE samples. This will enable the confident application of RNA-Seq to FFPE material to accurately profile: 1) transcriptional expression, 2) somatic mutations, and 3) chromosomal rearrangements. The strategy for the comprehensive workflow also includes resolving analysis challenges for FFPE RNA- Seq, including developing new bioinformatics tools to enhancethe identification of SNV and chromosomal rearrangements. The primary aims of this Phase I application are: Aim 1. Develop a rigorous qualification assay for FFPE RNA that is predictive of sequencing quality. Aim 2. Develop bioinformatics analysis
Technology keywords
Not reported
Other awards by this recipient
Verified by the same UEI. These are other public SBIR/STTR award pages, not a merged company record.
- AmplideX DeepNet, a new paradigm for deep learning analytical tools in the molecular diagnostic space
- Novel Strategies for Development of a Multiplexed Test with Expanded Content for Spinal Muscular Atrophy
- Novel Strategies for Enhanced Detection of Hemoglobinopathy Carriers
- Single cell prenatal testing of circulating trophoblasts using a the novel immunomagnetic Micro-Aperture Chip (IMAC) system
- A single test utilizing a unified multiplex PCR/CE workflow targeting five dominant inherited ataxias
Awards with the same topic code
Verified by an exact topic code match. This is not a text-similarity match.
- Bioinspired Green Glycolipids as Fugitive Dust Mitigation Agents
- Supercritical Fluid Cartridges for Calibration of Air Pollution Sensors
- Weight Loss and Endocrine Disrupting Chemicals (EDCs): Lifestyle interventions to lose weight and reduce EDC exposure in individuals with overweight/obesity
- High-Resolution Ground-Level AQ Monitoring System Using Hyper-local Low-cost Sensor Nodes and AI Forecasting
- Bringing PFAS Monitoring Home: An Integrated Magnetic Nanoparticle and Lateral Flow Assay System
Research funding history
23 SBIR/STTR records share this UEI (2011–2019). Reported award amounts total $12,427,799. Reported amounts are not federal obligations.
Phases: Phase I, Phase II
Agencies: Department of Health and Human Services