Adenoviral Mediated Gene Therapy for Experimental Glioma

Gliomas are the most common primary intracranial brain tumors and are thought to arise as a neoplastransformation of glial cells in the central nervous system. The prognosis for the disease is poor.surgical resection of the tumor followed by radiation or chemotherapy. This application describes analternative treatment strategies. The effectiveness of an adenovirus vector to deliver the herpes sikinase (tk) gene to inhibit selectively tumor cell growth upon receipt of ganciclovir (GCV) will beadenovirus vector will be specifically introduced into the tumor area by stereotactic injection; GCVsystemically. The plan is to optimize growth inhibition by determining the effectiveness of redosingdeveloping long term release of infectious virions into the surrounding environment.