COMPACT DEVICE FOR SOLVENT IDENTIFICATION

Not Available The U.S. Food and Drug Administration (FDA) requires that all blood shipped by interstate commerce be tested for certain transfusion transmissible diseases. Unfortunately, current tests can not provide rapid support for field medical emergencies that require blood in excess of the tested supply, especially when additional blood needs to be drawn from the available walking pool. Intelligent Optical Systems (IOS) proposes to develop and construct an innovative surface plasmon resonance optical waveguide (SPROW), based on label-free, wash-free, one-step reaction, that can simultaneously perform multiple transmissible disease assays with specificity, sensitivity, and simplicity. In this project, a microslide-based waveguide chip, immobilized with molecules, will be developed and integrated with optoelectronics for the simultaneous screening of multiple diseases. The system will be tested under FDA guidelines using the selected format to verify the required sensitivity and specificity. During Phase I of the project, the technical feasibility of the SPROW system will be demonstrated using HBV and HCV test antibodies. BENEFITS: A rapid and sensitive method for the detection and identification of pathogens has a wide variety of applications. Blood banks, diagnostic clinics, point of care facilities, and the food and pharmaceutical industries can all benefit from this technology.