TREATMENT OF ENDOTOXIC SHOCK WITH AN ADENOSINE 3 AGONIST

Not Available There is a growing need for new sensors to non-invasively monitor the physiologic status of casualties on the battlefield. Advances in the theoretical understanding of photon migration in tissue, as well as recent developments' of compact light sources and detectors, have made possible new, robust and non-invasive instruments. Currently, optical detectors limit the usefulness of optical diagnostic systems for deep tissue hemodynamics due to their cost, size, or insensitivity to low light levels. The proposed work is based on recent hemodynamic sensors development at RMD Inc. and Tufts University. We plan to produce prototype components for a compact, lightweight, hemodynamic monitoring system, and to demonstrate proof-of-principle design for an immature, non-invasive integrated solid-state optical sensor. The sensor is based on the measurement of deep tissue multi-spectral absorption coefficients, in conjunction with the measurement of blood flow induced Doppler broadening on detector arrays with single photon sensitivity. Using oxyhemoglobin as a marker, this novel system will simultaneously measure the hemoglobin, oxygen saturation concentration, and blood flow in surface and deep tissues. The proposed system will significantly improve monitoring of physiological status of battlefield casualties and make possible new applications requiring continuous monitoring of the full hemodynamic. BENEFITS: The development of a low cost, miniature full hemodynamic system will