SBIR/STTR Research Award
MICROBIOREACTORS FOR MANUFACTURING AUTOLOGOUS CELL BASED CANCER IMMUNOTHERAPIES
Award amount
$300,000Program and phase
SBIR · Phase IAward year
2017Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- National Institutes of Health
- Recipient company
- Pharyx, Inc.
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- N3JAU1TPNBH9
- Solicitation number
- Not reported
- Topic code
- NCI
Research abstract
The manufacture of personalized medicine products such as autologous cell based cancer immunotherapies is a tremendous challenge When the manufactured batch size is for a single patent new manufacturing systems are needed to reduce the cost and improve the quality of these individualized products The long term objectives of this project are to develop a microbioreactor based manufacturing platform to enable the low cost manufacture of autologous cell therapies at scales exceeding individual therapies per year Initial feasibility will be assessed by cultivating T cells in existing microbioreactors and optimizing process conditions for maximum cell density In addition process development to improve the efficiency of genetically modifying the target cells will be performed in order to improve product quality and process robustness Finally a microbioreactor system specifically for autologous cell therapy manufacturing with quality control sample preparation will be designed
Technology keywords
Not reported
Other awards by this recipient
Verified by the same UEI. These are other public SBIR/STTR award pages, not a merged company record.
- Development of Microbioreactor Technology for Obligate Anaerobes
- Development of Microbioreactor Technology for Obligate Anaerobes
Awards with the same topic code
Verified by an exact topic code match. This is not a text-similarity match.
- Mini-reflectance confocal microscope (Mini-RCM) for aiding skin cancer diagnosis and treatment
- Development of small molecule therapeutics targeting AR-V7 for prostate cancer
- Decentralized Clinical Trial of Effectiveness of EnergyPoints App to Guide Acupressure Use for Fatigue and Sleep Disturbances in Cancer Survivors
- Optimized targeted radiotherapy of pancreatic cancer
- Adaptive imaging for pioneering multiplexed spatial profiling of tumors and tissues for cancer research and diagnosis
Research funding history
3 SBIR/STTR records share this UEI (2008–2017). Reported award amounts total $1,150,000. Reported amounts are not federal obligations.
Phases: Phase I, Phase II
Agencies: Department of Energy, Department of Health and Human Services