SBIR/STTR Research Award
LIVER STEM CELLS AND HUMANIZED MICE: A NEW MODEL FOR HCV
Award amount
$300,000Program and phase
SBIR · Phase IAward year
2001Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- National Institutes of Health
- Recipient company
- STEMCELLS, INC.
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- Not reported
- Solicitation number
- Not reported
- Topic code
- Not reported
Research abstract
DESCRIPTION: This application proposes to use NOD/SCID mice transplanted
(intrasplenically or under kidney capsule) with human hepatocytes for HCV
infection. The project will first identify hepatocyte subpopulations that are
most susceptible to HCV infection, and examine the possible effects of
hepatocyte growth factor (HGF) on hepatocyte growth in the transplanted mice.
The same approach will also be applied to fumarylacetoacetate hydrolase (FAH)
mice to enrich transplanted human hepatocytes. For all of the optimization
procedures, hepatitis delta virus (HDV) will be used as a surrogate virus for
HCV. Eventually, these humanized mice will be tested for HCV infections.
PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE
Technology keywords
Not reported