Energy Efficient Tentage with Reduced Thermal Signature

Not Available A field-usable multi-analyte BW sensing system employing an integrated sample preconcentration stage is proposed. To enable operation in real-world environments, the system employs a particle filter and magnetic immunobeads to clean and concentrate the target analytes in the solution. A highly compact, imaging, optical arrangement subsequently monitors the sample fluid for a large number of analytes in parallel. By using a photo induced immobilization technique, a multitude of different antibodies is immobilized on the surface of a glass carrier, each type being located at a specific position on the chip. When sample fluid containing the analytes is flowed over the sensor surface, the top plane of the optical carrier chip is interrogated by an imaging ellipsometer to provide a spatially resolved measurement of the sample surface. This allows precise monitoring of binding events to the individual sensor fields. Use of semiconductor sources enables highly compact realization; employing several wavelengths further enhance the sensitivity. The imaging technique yields highly resolved information about the binding status of a vast number of different antibody fields without the need for labeling reagents. This system will be of high commercial interest for chemical and biological screening and for environmental monitoring applications. The proposed system is intended to serve as a compact, sensitive tool for analyzing environments on site for a large number of reagents. Combining sample pre-processing with the high sensitivity and labeless operation of multi-spectral ellipsometry methods and the fast readout of an extremely high number of parallel channels, this setup will find multiple commercial applications in drug screening, environmental monitoring, and DNA analysis applications.