SBIR/STTR Research Award

INVESTIGATION OF 3-DIMENSIONAL PARAMETERS FOR SAR MODELLING OF MUTAGENICITY

Award identifier c1595483d9f4fb32802fe5697b45a67e4fe46a566bc9905373ced26b353a0596Awarding agency Department of Health and Human Services

Award amount

$50,000

Program and phase

SBIR · Phase I

Award year

1988

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Award details

Awarding agency
Department of Health and Human Services
Branch
Not reported
Recipient company
Enslein Research, Inc.
Proposal award date
Not reported
Contract end date
Not reported
UEI
Not reported
Solicitation number
Not reported
Topic code
Not reported

Research abstract

IN THIS RESEARCH WE WILL INVESTIGATE THE APPLICABILITY OF 3-DIMENSIONAL PARAMETERS TO THE STRUCTURE-ACTIVITY MODELLINGOF MUTAGENICITY. THE MUTAGENIC ENDPOINTS WILL BE THE AMES TEST, AND EITHER THE MOUSE LYMPHOMA OR THE SYRIAN HAMSTER OVARY CELL ASSAY. THE PARAMETERS TO BE INVESTIGATED WILL INCLUDE POLARIZABILITY, ELECTRONIC CHARGES, MOMENTS OF INERTIA AND FUNCTIONS OF THESE, AREA, VOLUME, AND MOLECULAR CROSS-SECTIONAL AREA.

Technology keywords

Not reported

Agency intelligence

Department of Health and Human Services

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