New Instrument for Generating Combinatorial Libraries

The development of a new instrument for synthesizing combinatorial libraries is proposed. Theinstrument, coined SCAMP, has the potential to synthesize peptide arrays containing millions of relatedpeptides. It will be highly automated, and thus find use by those unskilled in the use of combinatoriallibraries. It has the further potential of being relatively inexpensive, and thus readily available to mostresearchers. Phase I will demonstrate the ability of SCAMP to synthesize peptides in a spatiallywell-defined array. The ultimate goal of this research is to develop a highly automated, user-friendlyinstrument for synthesizing large combinatorial arrays.