SBIR/STTR Research Award
A Liposomal Platform for Spontageous, Particleized Presentation of HIV Trimer Immunogens
Award amount
$599,897Program and phase
SBIR · Phase IAward year
2019Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- National Institutes of Health
- Recipient company
- POP Biotechnologies Inc.
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- ZWKMU75DGJY4
- Solicitation number
- Not reported
- Topic code
- NIAID
Research abstract
Over one million Americans andmillion people worldwide are infected with HIVmaking it one of the most pressing public health concerns of our timeUnfortunatelythere are no vaccines available and treatment requires lifelong anti retroviral therapiesThis proposal combines two technologies for the development of a vaccine against HIVEnva novel adjuvantspontaneous nanoliposome antigen particleizationSNAPanda state of the art antigennative flexibly linkedNFLtrimers of HIVEnve gBGThis proposal will accomplish the following technical objectivesProduce and provide well characterized cobalt porphyrin phosphoipidCoPoPCoPoP liposomes and NFL trimersAssess particleization parameters of His tagged BGNFL trimers with CoPoP liposomesCharacterize conformational stability of particleized NFL trimersDetermine the impact of antigen density in inducing HIV neutralization with rabbit SNAP immunizationAssess multiplexed particleization parameters with His tagged BGandcAssess multivalent IgG response following rabbit SNAP immunization with BGandcandCharacterize cobalt levels and His tag response in immunized subjectsRabbits will be vaccinated and sera tested for neutralizing antibodies to HIVThe neutralizing titer of SNAP NFL vaccinated rabbits will be significantly higher than standard vaccination methods
Technology keywords
Not reported
Other awards by this recipient
Verified by the same UEI. These are other public SBIR/STTR award pages, not a merged company record.
- Mosaic Display of Multivalent Tau and A-Beta peptides on Immunogenic SNAP Liposomes
- Liposome-displayed peptide vaccine against disseminated candidiasis by clinically-relevant Candida species
- Advanced testing of a hexavalent adjuvanted influenza vaccine platform for dose sparing, multiplexing, and rapid deployment
- Clinical Translation of Interstitial Chemophototherapy with Light-Activated Nanoparticulate Doxorubicin
- Mosaic Display of Multivalent Tau and A-Beta peptides on Immunogenic SNAP Liposomes
Awards with the same topic code
Verified by an exact topic code match. This is not a text-similarity match.
- Manufacturing and Formulation Process Development for a Prophylactic Cholera Phage Cocktail
- A first-in-class product for the clearance of high-risk human papillomaviruses
- A Rapid, Point-of-Care Diagnostic to Identify Viable Sexually Transmitted Infections, Reduce Overtreatment, and Prevent Emerging Antibiotic Resistance
- Optimization, Pharmacokinetics, and Efficacy of an IgG Protease for the Treatment of Immune Thrombocytopenia and Other IgG-Mediated Autoimmune Diseases
- Nebulized ALX1 as a treatment for Pseudomonas aeruginosa infections in bronchiectasis patients
Research funding history
12 SBIR/STTR records share this UEI (2018–2025). Reported award amounts total $8,781,806. Reported amounts are not federal obligations.
Phases: Phase I, Phase II
Agencies: Department of Health and Human Services