SBIR/STTR Research Award
THERAPEUTIC COAGULATION INHIBITOR
Award amount
$50,000Program and phase
SBIR · Phase IAward year
1991Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- Not reported
- Recipient company
- COR THERAPEUTICS, INC.
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- Not reported
- Solicitation number
- Not reported
- Topic code
- Not reported
Research abstract
WE WILL SCREEN COMMERCIALLY AVAILABLE SNAKE VENOMS FOR SELECTIVE ANTITHROMBOTICS, SPECIFICALLY INHIBITION OF FACTOR VII/TISSUE FACTOR AND PROTHROMBINASE. ULTRAFILTRATES OF 70 SNAKE VENOMS WILL BE USED TO LOOK FOR LOW MW INHIBITORS THAT WOULD INHIBIT THE ABOVE ENZYMES IN CHROMOGENIC ASSAYS. ADDITIONAL ASSAYS WILL BE DONE TO VERIFY THE EFFICACY, FOLLOWED BY BIOCHEMICAL PURIFICATION AND CHARACTERIZATION. CLONING AND LARGE SCALE PRODUCTION WILL FORM THE BASIS FOR PHASE II STUDY.
Technology keywords
Not reported