Controlled intracavitary prostate cancer hyperthermia

This proposal defines the development and evaluation of a dedicated microwave device for rapid, autstandardized fixation of tissue biopsies for histopathological examination. Microwave energy is useddilute aldehyde or salt solutions to produce fixation results that are equal in quality to chemicalto freezing methods. Microwave fixation is in limited use by many pathology laboratories throughoutmicrowave ovens are the primary microwave device in use in the laboratory environment but have sever(e.g., nonuniform irradiation) and safety (e.g., cannot adequately vent toxic chemicals) limitationsmicrowave fixation device is important for patient care and research because it shortens the preparaspecimen in the laboratory, improves technician safety and may improve the accuracy of diagnoses. Wa single mode microwave device that uniformly irradiates biopsy tissue and controls final irradiationoninvasively using a proven radiometer; and 2) evaluate the microscopic anatomy and staining qualitspecial stains (e.g., Masson Trichrome, PAS, silver stains) of rat tissues (e.g., liver, brain, muscthe prototype microwave device.