SBIR/STTR Research Award
THE PURPOSE OF THIS PROJECT IS TO LABEL MONOCLONAL ANTIBODIES WITH ASTATINE-211 FOR USE IN RADIO-IMMUNOTHERAPY.
Award amount
$50,000Program and phase
SBIR · Phase IAward year
1986Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- Not reported
- Recipient company
- NEORX CORPORATION
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- Not reported
- Solicitation number
- Not reported
- Topic code
- Not reported
Research abstract
THE PURPOSE OF THIS PROJECT IS TO LABEL MONOCLONAL ANTIBODIES WITH ASTATINE-211 FOR USE IN RADIO-IMMUNOTHERAPY.THE GOAL OF THE PROPOSED RESEARCH IS TO DEVELOP A METHOD TO INCORPORATE ASTATINE INTO ANTIBODIES SUCH THAT THE ASTATINE LABILE IN VITRO OR IN VIVO. IN THE INVESTIGATION, TWO DIFFERENT APPROACHES TO LABELING WILL BE COMPARED. ONE APPROACH WILL BE DIRECT LABELING WITH ASTATINE; THE OTHER APPROACH WILL INVOLVE THE USE OF ASTATINATED SMALL MOLECULES. THE LATTER APPROACH WILL INCLUDE DEVELOPMENT OF METHODS TO FIRMLY ATTACH THE ASTATINE TO THE SMALL MOLECULES.
Technology keywords
Not reported