SBIR/STTR Research Award

LiquidCell EM System with Temperature Control for Biological Imaging

Award identifier 6a8e0c30b786475e0028e0369f982d7e8d3eeb795b407623a07f32dbf89048f1Awarding agency Department of Health and Human Services · National Institutes of Health

Award amount

$148,176

Program and phase

SBIR · Phase I

Award year

2014

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Award details

Awarding agency
Department of Health and Human Services
Branch
National Institutes of Health
Recipient company
ZINSTRUMENTS, LLC
Proposal award date
Not reported
Contract end date
Not reported
UEI
Not reported
Solicitation number
PA13-234
Topic code
NIGMS

Research abstract

DESCRIPTION (provided by applicant): One of the most challenging, yet highly rewarding tasks in biological research is to visualize with high spatial resolution the structure of molecula machines and their interactions in cellular function under physiological conditions, such as in 37 C aqueous environment. This proposed LiquidCell EM system with precise temperature control enables direct imaging of many dynamic biological processes in truly native environments with ultra high resolution using transmissionelectron microscopy. In this proposal, we will fabricate the self-contained liquid cells with ultra-thin viewing windows. Precise temperature control of 37+/-0.1 C will be achieved through microfluidic device fabrication. Test experiments of imaging individual proteins, protein assembly and live cell functions will be performed to optimize the system for in vivo biological imaging under physiological conditions. PUBLIC HEALTH RELEVANCE PUBLIC HEALTH RELEVANCE: LiquidCell EM system with te

Technology keywords

Not reported

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Agency intelligence

Department of Health and Human Services

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