CYTOCHROME P450 INHIBITION SCREENS FOR METABOLISM

Not Available Polarization imaging holds promise for providing significant improvements in contrast in a number of target detection and discrimination applications. In several recent development efforts, it has been demonstrated that manmade objects have a significantly stronger polarization signal than natural backgrounds resulting in good contrast that complements the conventionally imaged infrared signature. Other recent research has suggested that polarization sensing may increase detection range through optically dense media such as fog or aerosol laden atmosphere. However, these experimental systems frequently require long data acquisition times, which results in artifacts in the polarization imagery due to platform or target motion. Additionally, calibration and investigation of systematic errors in these systems is difficult and robust calibration procedures have not been fully demonstrated. SY Technology, Inc proposes an aggressive instrument develop program beginning with modeling and prototype design efforts in this Phase I task. Infrared polarization signatures for typical scenarios will be modeled followed by analysis of various polarimetric detection schemes meeting the 30 Hz frame rate requirement. Once the optimal detection scheme is chosen, the prototype instrument will be designed complete with component specifications, schematics, data reduction, and calibration algorithms. A thorough performance analysis of the design will also be performed. BENEFITS: It is ant