THE LONG-TERM OBJECTIVE OF THIS PROJECT IS TO DEVELOP A PRACTICAL VOLUME FLOW MEASURING DOPPLER SYSTEM FOR QUANTI- FICATION OF BLOOD VELOCITIES AND FLOWS THROUGHOUT THE BODY.

THE LONG-TERM OBJECTIVE OF THIS PROJECT IS TO DEVELOP A PRACTICAL VOLUME FLOW MEASURING DOPPLER SYSTEM FOR QUANTI- FICATION OF BLOOD VELOCITIES AND FLOWS THROUGHOUT THE BODY. HEALTH CARE APPLICATIONS OF SUCH A DEVICE INCLUDE EVALUATIONOF ARTERIAL OCCLUSIVE DISEASE, VENOUS OCCLUSIVE DISEASE, EXTRACRANIAL ARTERIAL OCCLUSIVE DISEASE, AND MONITORING OF CARDIAC OUTPUT AND ORGAN PERFUSION. DURING PHASE I, PRACTI-CAL TRANSDUCER DESIGNS TO MEASURE ARTERIAL BLOOD VELOCITY AND FLOW WILL BE DEVELOPED THROUGH BOTH MATHEMATICAL SIMULA-TION AND EXPERIMENTATION. THE ELECTRONIC CIRCUITRY AND COMPUTER SOFTWARE TO IMPLEMENT THE ANGLE-INDEPENDENT DOPPLERWILL BE DESIGNED AND TESTED. A PROTOTYPE ANGLE-INDEPENDENT DOPPLER SYSTEM SUITABLE FOR USE IN THE CLINICAL SETTING WILLBE DESIGNED AND CONSTRUCTED. IN PHASE II, CLINICAL STUDIES WILL BE INITIATED TO DEMONSTRATE THE EFFECTIVENESS OF ANGLE-INDEPENDENT VELOCIMETRY FOR BLOOD FLOW MEASUREMENT, AND TO IDENTIFY KEY APPLICATION AREAS. THE PROTOTYPE SYSTEM WILL BE FURTHER REFINED TO A PRACTICAL UNIT SUITABLE FOR COMMERCIAL APPLICATION.