NON OLIGONUCLEOTIDE ANALOGS AS ANTI HBV AGENTS

Not Available We propose to design and build a generic aerosol collector and detector interface that will incorporate a MesoSystems aerosol collector, fluidic delivery system, lysis stage, electronic control system, and the Utah State University whole cell detector, which serves as an example of the types of BW detectors now emerging for military use. The resulting prototype portable detector will be functional at the conclusion of Phase I, but additional work on the plasma lysis section and polymerase chain reaction (PCR) interconnection will not be completed until the Phase I option and Phase II awards are granted Special design effort will be spent on making a flexible, disposable reagent cartridge that solves many of the fluidic interconnection problems and biological warfare (BW) instrument contamination concerns. BENEFITS: MesoSystems will drive the standardization of the interfaces because of: Micromachining experience Collector miniaturization Microfluidic work Familiarly with detectors.