SBIR/STTR Research Award
Vitamin D Based Anticancer Prodrugs
Award amount
$638,359Program and phase
SBIR · Phase IIAward year
1997Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- Not reported
- Recipient company
- Tetrionics, Inc.
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- Not reported
- Solicitation number
- Not reported
- Topic code
- Not reported
Research abstract
It is now well established that 1alpha, 25-dihydroxyvitamin D3 not only mediates calcium homeostasisignificant cellular activity in tissues not related to calcium homeostasis. This seco-Suiteroid horpromote cellular differentiation and inhibit proliferation in a number of normal and malignant cellagent for malignancy, 1,25(OH)2D3 has limited potential due to its calcemic activity. We will syntheseries of 19-nor-vitamin D analogs and their pro-drug precursors as potential anti-cancer therapeutisuggest that these 19-nor compounds retain differentiating and antiproliferative activity and exhibiactivity.
Technology keywords
Not reported