SBIR/STTR Research Award
IGF::OT::IGF TOPIC 372 DEVELOPMENT AND VALIDATION OF NON-MOUSE REAGENTS TO ENABLE PRECLINICAL DEVELOPMENT OF NOVEL THERAPEUTICS- MOONSHOT
Award amount
$2,000,000Program and phase
SBIR · Phase IIAward year
2019Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- National Institutes of Health
- Recipient company
- SYNBAL INC
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- PZKSBR7YKLF4
- Solicitation number
- Not reported
- Topic code
- NCI
Research abstract
In this Fast track SBIR grant we aimby the end of Phase IIto prepare and commercialize a fully humanized rat with Knock out of many rat drug metabolism related CYPsinout Rat Drug Metabolism CYPModeland Knock in of the human counterpartIN PHASE I we will develop an Active GenesGene DriveAG GDrata rat with a properly configured Casto power Active GeneticsAGANDwe will prepare the first CYPKout KinCYP EAG GD is a new technology invented by Synbal s founders which allows Super Mendelian conversion to homozygositythusit can dramatically accelerate development of models with multiple genetic changesThese kinds of animals can be quickly crossedusing Active Genetics into immuno deficient or other rat strains useful in modeling oncology and other diseasesThusthis proposal answers the request for non mouse preclinical models to test therapeutics within animal models of diseaseIn Phase II we will prepare a fully humanized rat ready for sale to the pharmaceutical research communityAdditionallythe demonstration of Active Genetics in the ratis an entry point in other vertebrateslike dogspigs or monkeys and therefore it will have a huge implication on the future of toxicity and efficacy testing
Technology keywords
Not reported
Other awards by this recipient
Verified by the same UEI. These are other public SBIR/STTR award pages, not a merged company record.
- Triple humanized ACE2-TMPRSS-FcGRT mouse models for COVID research in the C57BU6 and BALBIc backgrounds.
- Triple humanized ACE2-TMPRSS-FcGRT mouse models for COVID research in the C57BU6 and BALBIc backgrounds.
- Topic 372: Development of the Fully Humanized 9-in-9-out Rat Drug Metabolism-CYP450 Model, Using the Active Genetic: Gene Drive Technology
Research funding history
4 SBIR/STTR records share this UEI (2018–2022). Reported award amounts total $4,100,259. Reported amounts are not federal obligations.
Phases: Phase II, Phase I
Agencies: Department of Health and Human Services