SBIR/STTR Research Award

HHSN261201400018C;EPOTHILONE D FORMULATED IN POLYMER MICELLE NANOPARTICLES; POP: 09/17/2014 TO 05/16/2016

Award identifier 096c13ffcdb36694876c1edba2faa493f63c2140b1fb3a22b7f6d12e483a3703Awarding agency Department of Health and Human Services · National Institutes of Health

Award amount

$944,978

Program and phase

SBIR · Phase II

Award year

2014

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Award details

Awarding agency
Department of Health and Human Services
Branch
National Institutes of Health
Recipient company
INTEZYNE TECHNOLOGIES, INC.
Proposal award date
Not reported
Contract end date
Not reported
UEI
Not reported
Solicitation number
Not reported
Topic code
NCI

Research abstract

This project aims to optimize the lead formulation of epothilone D encapsulated in a stable nanoparticle for the treatment of solid malignancies, and assist in providing for the GMP manufacturing and GLP toxicology studies required for IND submission and translation into human clinical trials. The optimized formulation should demonstrate improvements in plasma pharmacokinetics in a cannulated rat model as well as improved antitumor efficacy in tumor xenograft models in mice. The optimized lead formulation technique will be transferred to Intezyne's GMP manufacturing partner for production of material for the GLP animal studies necessary for IND submission. PUBLIC HEALTH RELEVANCE

Technology keywords

Not reported

Awards with the same topic code

Verified by an exact topic code match. This is not a text-similarity match.

Agency intelligence

Department of Health and Human Services

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