NORMAL TISSUE SURROUNDING THE TUMOR WE PROPOSE TO DEVELOP A NUMBER OF NOVEL TECHNIQUES INVOLVING SIMULTANEOUS IMAGING OF LASER-INDUCED FLUORESCENCE IN MULTIPLE WAVELENGTH BANDS FROM HEMATOPORPHYRIN DERIVATIVE BEARING TISSUE, PERMITTING CONTRAST

NORMAL TISSUE SURROUNDING THE TUMOR WE PROPOSE TO DEVELOP A NUMBER OF NOVEL TECHNIQUES INVOLVING SIMULTANEOUS IMAGING OF LASER-INDUCED FLUORESCENCE IN MULTIPLE WAVELENGTH BANDS FROM HEMATOPORPHYRIN DERIVATIVE BEARING TISSUE, PERMITTING CONTRAST ENHANCEMENT FOR CANCER-TUMOR LOCALIZATION WITH ULTRA HIGH PRECISION AND ACCURACY. SEVERAL OPTICAL CAVITIES INVOLVING GEOMETRIES TO MINIMIZE SCAR TISSUE FORMATION AND SPARE THE NORMAL TISSUES SURROUNDING THE TUMOR WILL BE EXPLORED. THE PROPOSED DEVICE SHOULD CONTROL THE DEPTH OF LASER ENERGY AND INSURE THREE-DIMENSIONAL REGULATION OF EXCISION, WHICH SHOULD HAVE A MAJOR IMPACT IN THE CARE OF A GREAT MANY PATIENTS WHO REQUIRE SURGERY.