SBIR/STTR Research Award

WE WILL IDENTIFY AND CHARACTERIZE ALL THE MHC CLASS II BETA CHAIN GENES AND PSEUDOGENES IN A CELL LINE CONTAINING A SINGLE COPY OF THE MHC.

Award identifier 5d692af39348b833e2ac0aad6f1224c83d3ad8fd1b424c9400e6f7fca0978270Awarding agency Department of Health and Human Services

Award amount

$50,000

Program and phase

SBIR · Phase I

Award year

1985

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Award details

Awarding agency
Department of Health and Human Services
Branch
Not reported
Recipient company
NEUGENESIS CORPORATION
Proposal award date
Not reported
Contract end date
Not reported
UEI
Not reported
Solicitation number
Not reported
Topic code
Not reported

Research abstract

WE WILL IDENTIFY AND CHARACTERIZE ALL THE MHC CLASS II BETA CHAIN GENES AND PSEUDOGENES IN A CELL LINE CONTAINING A SINGLE COPY OF THE MHC. THE SEQUENCE INFORMATION OBTAINED WILL BE USED TO CONSTRUCT A SERIES OF VECTORS THAT PERMIT RAPID CONSTRUCTION OF HYBRID HUMAN-MURINE CLASS II GENES CONTAINING THE POLYMORPHIC FIRST DOMAIN OF EACH HLA CLASS II GENE OF ANY INDIVIDUAL. THESE HYBRID GENES WILL BE USED TO TRANSFECT LYMPHOCYTES FOR MURINE IMMUNIZATIONS AND THUS PRODUCTION OF MONOCLONAL ANTIBODIES DIRECTED AGAINST ELLELE SPECIFIC EPITOPES OF THE HUMAN GENES. THE METHODS WILL BE APPLIED TO OBTAIN A FULL CHARACTERIZATION OF THE GENES EXPRESSED IN DR3 AND DR4 INDIVIDUALS, TO EVALUATE THE HETEROGENEITY WITHIN THESE SEROLOGIC TYPES, AND TO PREPARE MONOCLONAL ANTISERA SUBDIVIDING THE DR3 AND DR4 GROUPS.

Technology keywords

Not reported

Agency intelligence

Department of Health and Human Services

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