SBIR/STTR Research Award
DECONTAMINATION OF PLATELET CONCENTRATES
Award amount
$50,000Program and phase
SBIR · Phase IAward year
1987Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- Not reported
- Recipient company
- Advanced Genetics Research
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- Not reported
- Solicitation number
- Not reported
- Topic code
- Not reported
Research abstract
THE OVERALL OBJECTIVE OF THE RESEARCH IS TO DEFINE A SYSTEM FOR DECONTAMINATING PLATELET CONCENTRATES. PRESENT SCREENING OF DONATED BLOOD DOES NOT DETECT ALL POTENTIALLY INFECTIOUS CONTAMINANTS. THEREFORE, IT IS IMPORTANT TO FINDA MEANS OF RENDERING BLOOD PRODUCTS NONSPECIFICALLY NONINFECTIOUS TO REDUCE THE RISK OF VIRAL INFECTION AND BACTERIAL SEPSIS ASSOCIATED WITH THERAPEUTIC USE OF PLATELETCONCENTRATES. DIAMOND SCIENTIFIC COMPANY PROPOSES TO DEMONSTRATE THE ABILITY TO INACTIVATE AN ANIMAL-VIRUS MODEL IN PLATELET CONCENTRATES. THE EFFECTS OF THE INACTIVATION TREATMENT ON THE FOLLOWING WILL BE EXAMINED: (1) GROSS PLATELET MORPHOLOGY, BY MEASURING PLATELET COUNT AS A FUNCTION OF INACTIVATION TIME; (2) RESPONSE OF PLATELETS TO AGGREGATING AGENTS; AND (3) PLATELET ACTIVATION BY FLUORESCENT ANTIBODY ASSAY. THIS RESEARCH HAS THE POTENTIAL TO BE COMMERCIALLY USEFUL IN SAFEGUARDING THE ESTIMATED 5 TO 7 MILLION UNITS OF PLATELETS TRANSFUSED ANNUALLY.
Technology keywords
Not reported