Diode Laser-Based Ketosis Sensor

This Small Business Innovation Research Phase I proposal will lead to the development of a sensor for detection of the early onset of ketosis by breath acetone measurements. The device will be hand-held, lightweight, and battery-powered. Near-infrareddiode laser measurement of a gas-solid reaction product of acetone will afford increased sensitivity. The sensor will provide a rapid measurement of breath acetone concentration with 1.0 ppm to sub ppm detection limit from a single exhalation. Thetechnology will provide important non-invasive monitoring of the diabetic state. Other applications include the management of ketogenic diets for epilepsy treatment, the evaluation of the nutritional status of emergency personel in extended fieldsituations, and monitoring breath levels acetone for dairy cattle.