CHARACTERIZATION OF CLONIDINE DISPLACING SUBSTANCE

RECENT MOLECULAR PHARMACOLOGICAL STUDIES HAVE INDENTIFIED A NEW RECEPTOR CLASS WHICH RESEMBLES ALPHA 2 ADRENOCEPTORS BUT BECAUSE OF SUBTLE DIFFERENCE HAS BEEN NAMED BY A VARIETY OF DESCRIPTORS INCLUDING IMIDAZOLE RECEPTORS. THESE RECEPTORS HAVE BEEN IMPLICATED AS BEING IMPORTANT IN CONTROLLING HYPERTENTION. HOWEVER, STUDIES TO FURTHER DEFINE THE PHYSIOLOGIC IMPORTANCE OF THIS RECEPTOR CLASS HAVE BEEN LIMITED BY THE LACK OF INFORMATION AVAILABLE ON THE MOLECULAR STRUCTURE OF THE ENDOGENOUS LIGAND(S) AND THE RECEPTORS. WE WILL USE THE STRUCTURES OF THE ENDOGENOUS LIGAND(S) AS LEADS FOR THE DESIGN AND SYNTHESIS OF NEW THERAPEUTIC AGENTS TO INTERACT WITH IMIDAZOLE RECEPTORS.