A CONTROLLED RELEASE POROPLASTIC WOUND DRESSING WITH BACITRACIN AND POLYMIXIN B

A CONTROLLED RELEASE ANTIBIOTIC WOUND DRESSING IS TO BE DEVELOPED FOR ADMINISTRATION OF BACITRACIN AND POLYMIX B. THE DRESSING IS TO BE EASILY APPLIED AND CONFORMABLE TO WOUND SURFACES. BOTH ANTIBIOTICS ARE TO BE MAINTAINED AT EFFECTIVE LEVELS WITHIN WOULDS FOR THREE DAYS, PREVENTING INFECTION FOR THIS PERIOD OF TIME. THE DRESSING IS TO BE INCORPORATED INTO POROPLASTIC CELLULOSE TRIACETATE MEMBRANES IN A FORMULATION DEVELOPED TO PROVIDE THE REQUIRED FUNCTIONAL PROPERTIES. THE EXPERIMENTAL APPROACH TO BE FOLLOWED IN DEVELOPMENT WILL BE BASED UPON EXPERIENCE GAINED IN DEVELOPING THE POROPLASTIC MEMBRANE CONTROLLED RELEASE DRESSING FOR DELIVERY OF GENTAMICIN AND CLINDAMYCIN PHOSPHATE. DURING PHASE I, REQUIRED ANALYTICAL METHODS WILL BE VALIDATED. THE SOLUBILITY BEHAVIOR OF THE ANTIBIOTICS WILL BE INVESTIGATED TO ESTABLISH THE BASIS FOR DRESSING FORMULATION. INITIAL DRESSING FORMULATIONS WILL BE PREPARED, AND THEIR ANTIBIOTIC DELIVERY PROPERTIES WILL BE STUDIED IN DIFFUSION CELLS.