SBIR/STTR Research Award

THE OBJECT OF THIS PROJECT IS TO PRODUCE A KIT THAT UTILIZES ANTI-CSAP MONOCLONAL ANTIBODIES (MABS) FOR CLINICAL RADIOIMMUNODETECTION (RAID) OF COLORECTAL AND PANCREATIC CANCERS.

Award identifier 6e2814200414f95b5a831f81b62c9b3eb54a5f0cb405bfd5f6215ce4c796b201Awarding agency Department of Health and Human Services

Award amount

$50,000

Program and phase

SBIR · Phase I

Award year

1985

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Award details

Awarding agency
Department of Health and Human Services
Branch
Not reported
Recipient company
IMMUNOMEDICS, INC.
Proposal award date
Not reported
Contract end date
Not reported
UEI
S4NHH3294XM6
Solicitation number
Not reported
Topic code
Not reported

Research abstract

THE OBJECT OF THIS PROJECT IS TO PRODUCE A KIT THAT UTILIZES ANTI-CSAP MONOCLONAL ANTIBODIES (MABS) FOR CLINICAL RADIOIMMUNODETECTION (RAID) OF COLORECTAL AND PANCREATIC CANCERS. PHASE I WILL BE DEVOTED TO SELECTION OF HYBRIDOMAS WITH SPECIFICITY TO CSAP, AND MABS THAT ARE SUITABLE FOR IMAGING. IT WILL BE ACHIEVED BY INVESTIGATING THEIR IN VIVO DISTRIBUTION IN TUMOR AND NONTUMOR TISSUES USING AN ANIMAL MODEL. PHASE II INVOLVES: 1.SELECTION OF SUITABLE IRRELEVANT ANTIBODIES FOR SUBTRACTION. 2.RAID OF XENOTRANSPLANTED HUMAN TUMORS IN ANIMAL MODELS BY SUBTRACTION, USING I-131 AND I-123 TO LABEL THE SPECIFIC AND IRRELEVANT MABS RESPECTIVELY. 3.COMPARISON OF THE IMAGING EFFICIENCY OF A SINGLE ANTI-CSAP MAB TO THAT OF: A.POLYCLONAL ANTI-CSAP ANTIBODIES; C.ANTI-CEA MABS; AND D.MIXTURES OF ANTI-CSAP AND ANTI-CEA MABS. PRELIMINARY CLINICAL RAID STUDIES WITH ANTI-CSAP MABS ARE EXPECTED AT THE END OF THIS PHASE.

Technology keywords

Not reported

Other awards by this recipient

Verified by the same UEI. These are other public SBIR/STTR award pages, not a merged company record.

Research funding history

47 SBIR/STTR records share this UEI (1985–2013). Reported award amounts total $14,645,618. Reported amounts are not federal obligations.

Phases: Phase I, Phase II

Agencies: Department of Health and Human Services

Agency intelligence

Department of Health and Human Services

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