SBIR/STTR Research Award
Nanobind FFPE DNA/RNA Extraction
Award amount
$224,338Program and phase
SBIR · Phase IAward year
2014Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- National Institutes of Health
- Recipient company
- Circulomics Inc.
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- DF5ZDMUZJPH7
- Solicitation number
- ES13-009
- Topic code
- NIEHS
Research abstract
DESCRIPTION (provided by applicant): Nanobind FFPE DNA/RNA Extraction Despite the growing need for and the demonstrated potential advantages of molecular biomarkers, it has proven difficult to routinely employ them in the diagnosis and management of patients. One reason for this failure has been the logistical challenges of obtaining, rapidly processing, storin, and transporting quick-frozen tissue samples in clinical settings. Standard hospital tissue processing involves fixation in formaldehyde, followedby embedding in paraffin blocks to generate Formalin Fixed Paraffin Embedded (FFPE) tissue samples. If these FFPE samples can be harnessed for routine molecular analysis, the potential for revolutionizing current medical practice exists. FFPE blocks obtained in hospital pathology departments could then be routinely assayed using the newer molecular methods. Moreover, since FFPE samples are usually stored for many years by hospital pathology departments, retrospective molecular evaluations could also be
Technology keywords
Not reported
Other awards by this recipient
Verified by the same UEI. These are other public SBIR/STTR award pages, not a merged company record.
- Rapid Method to Enhance and Shape Long-Read Sequencing Read Length Distributions
- Nanostructured Magnetic Disks for Wide Range Size Selection in NGS Library Preparation and PCR Purification
- High Quality, High Integrity Nucleic Acid Extraction from FFPE Tissues
- Size Selection Purification Using a Thermoplastic Silica Nanomaterial
- PicoSep - A Microfluidic Platform for Single Molecule DNA and RNA Sizing
Awards with the same topic code
Verified by an exact topic code match. This is not a text-similarity match.
- Bioinspired Green Glycolipids as Fugitive Dust Mitigation Agents
- Supercritical Fluid Cartridges for Calibration of Air Pollution Sensors
- Weight Loss and Endocrine Disrupting Chemicals (EDCs): Lifestyle interventions to lose weight and reduce EDC exposure in individuals with overweight/obesity
- High-Resolution Ground-Level AQ Monitoring System Using Hyper-local Low-cost Sensor Nodes and AI Forecasting
- Bringing PFAS Monitoring Home: An Integrated Magnetic Nanoparticle and Lateral Flow Assay System
Research funding history
11 SBIR/STTR records share this UEI (2012–2020). Reported award amounts total $10,886,893. Reported amounts are not federal obligations.
Phases: Phase II, Phase I, Phase II – Direct to Phase II
Agencies: Department of Health and Human Services