STRUCTURE-BASED DEVELOPMENT OF HIV ATTACHMENT INHIBITORS

Not Available Microfluidic technology makes available a miniaturized means by which chemical reactants can be brought together on the microscale, fluidic sampling and dispensing can be automated, and the unique properties of low Reynolds number flow can be used to achieve new methods for fluid and sample separation, mixing, and analysis. Much progress has been made in technologies requiring the use of microfluidics, but a fundamental problem that still remains is the interface by which microfluidic systems are connected to the larger, macroscopic world. Thus far, most laboratory prototype systems have relied upon bulky, expensive, and fragile small-bore tubing and connectors for interconnections. HPLC fittings and tubing are very popular for this purpose. Even while the microfluidic system can in some cases be inexpensively produced by batch fabrication methods, the introduction of small-bore tubing and connectors increases the cost of such a system drastically. JCP Technologies proposes to develop a new strategy for modular microfluidic interconnections based upon a novel means for microfabrication called soft lithography. This strategy will emphasize modularity, low cost of manufacture, adaptability to the existing methods of fluidic interconnects, low dead volumes, and the ability to be disassembled and reassembled with precision, positive fastening mechanisms. BENEFITS: The proposed work will provide for the microfluidics markets what printed circuit boards have allowed in th