OPEN LITERATURE THE OBJECTIVE OF THIS PROGRAM IS TO ESTABLISH AN INFRASTRUCTURE UNDER WHICH AGENTS THAT DEMONSTRATE POTENTIAL CHEMOPREVENTIVE ACTIVITY CAN BE IDENTIFIED.

OPEN LITERATURE THE OBJECTIVE OF THIS PROGRAM IS TO ESTABLISH AN INFRASTRUCTURE UNDER WHICH AGENTS THAT DEMONSTRATE POTENTIAL CHEMOPREVENTIVE ACTIVITY CAN BE IDENTIFIED. RECENT DISCOVERIES WITH SMALL CLASSES OF AGENTS HAVE SHOWN CHEMOPREVENTIVE ACTIVITY IN ANIMAL MODELS FOR HUMAN CANCERS, AND CLINICAL TRIALS FOR SEVERAL OF THESE ARE NOW BEING PLANNED. AN IMMEDIATE GOAL OF THIS PROJECT IS TO PRIORITIZE AGENTS IDENTIFIED FROM REPORTS IN THE OPEN LITERATURE. IN SO DOING, THE MECHANISM FOR DATA COLLECTION AND EVALUATION CAN BE ESTABLISHED, LEADING TO A LONG-TERM GOAL OF CONTINUOUS MONITORING TO INCLUDE NEW DATA WITHIN THE ESTABLISHED HIERARCHY OF EFFICACY, TOXICITY, AVAILABILITY, ETC. IN THIS WAY A SYSTEM FOR INFORMATION THE METHODOLOGY TO BE EMPLOYED CONSISTS OF: A COMPREHENSIVE SURVEY OF THE OPEN LITERATURE (DURING WHICH SEARCH PARAMETERS FOR CONTINUED SURVEILLANCE WILL BE DEVELOPED); AN ANALYSIS OF THE RESULTANT MATERIAL FOUND PERTINENT (DURING WHICH THE PARAMETERS FOR ANALYSIS WILL BE ESTABLISHED); AND THE GENERATION OF A DATABASE RANKING THE AGENTS ACCORDING TO EFFICACY, TOXICITY, ETC. (DURING WHICH THE DATABASE DESIGN WILL BE GENERATED). THE RESULTS OF PHASE I WILL BE NOT ONLY A MASTER LIST OF COMPOUNDS FOR WHICH INFORMATION IS NOW AVAILABLE, BUT A MECHANISM BY WHICH THE CONTINUED UPDATING OF SUCH A LIST WILL BE POSSIBLE. PHASE II EFFORT WOULD CONSIST OF CONTINUED GROWTH OF THE DATABASE AND ESTABLISHMENT OF A DISTRIBUTION NETWORK.