DEVELOPMENT OF A DETECTOR FOR ELECTROPHILIC CARCINOGENS

THE PHASE I OBJECTIVES ARE: (1) DEVELOP AN ELECTRONIC SAMPLING DEVICE THAT PROVIDES A MEASURE OF THE ELECTROPHILICITY OF CHEMICALS IN LIQUIDS; (2) COMPARE THE RESPONSES OF THIS DEVICE WITH THOSE OF A PHYSICOCHEMICAL CARCINOGEN-SCREENING TEST (THE KE TEST) FOR KNOWN GENOTOXIC AND NONGENOTOXIC CARCINOGENS AND NONCARCINOGENS; (3) APPLY AN ESTABLISHED BATTERY SELECTION METHOD, THE CPBS OR CARCINOGENICITY PREDICTION AND BATTERY SELECTION METHOD, TO DETERMINE HOW THE ELECTRONIC DEVICE CAN BE USED MOST EFFICACIOUSLY IN A BATTERY OF CARCINOGEN-SCREENING TESTS; AND (4) INITIATE THE DEVELOPMENT OF AN ALTERNATIVE MEANS OF PRODUCING EXCESS ELECTRONS FOR USE WITH THE ELECTRONIC SAMPLING DEVICE THAT DOES NOT REQUIRE IONIZING RADIATION. ACCOMPLISHING THESE FOUR OBJECTIVES WILL PROVIDE A FIRM BASIS FOR THE PHASE II OBJECTIVE OF DEVELOPING AN ELECTRONICCARCINOGEN-MONITORING SYSTEM THAT COULD BE USED IN A VARIETY OF APPLICATIONS HAVING COMMERCIAL POTENTIAL THAT EXCEEDS $100 MILLION/YEAR.