SBIR/STTR Research Award
MONOCLONAL ANTIBODIES AGAINST THE MHC OF INBRED RATS
Award amount
$50,000Program and phase
SBIR · Phase IAward year
1987Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- Not reported
- Recipient company
- Analex Space Systems, Inc.
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- Not reported
- Solicitation number
- Not reported
- Topic code
- Not reported
Research abstract
THE OBJECTIVES OF THIS PROPOSAL ARE TO: (1) PRODUCE ALLOTYPIC MONOCLONAL ANTIBODIES THAT DISTINGUISH CLASS I ANDCLASS II ANTIGENS CODED BY THE RTI LOCI MAJOR HISTOCOMPATIBILITY COMPLEX (MHC) IN THE LABORATORY RAT, AND (2) CHARACTERIZE THE ANTI-MHC MONOCLONAL ANTIBODIES BY BIOCHEMICAL AND GENETIC METHODS TO DETERMINE THEIR ANTIGENIC SPECIFICITY FOR CLASS I AND CLASS II ANTIGENS OF DIFFERENT MHC HAPLOTYPES USING 11 STRAINS OF INBRED RATS. THE ANTIBODIES WILL BE USED IN COMBINATION WITH OTHER PROCEDURES FOR GENETIC DEFINITION WITHIN THE MHC. PHASE I RESEARCH INCLUDED INDUCTION AND CHARACTERIZATION OF ALLOTYPIC MONOCLONAL ANTIBODIES AGAINST THE 10 KNOWN HAPLOTYPES OF THE RAT MHC. PHASE II WILL INCLUDE PRODUCTION AND CHARACTERIZATION OF MONOCLONAL ANTIBODIES AGAINST THE 10 KNOWN HAPLOTYPES OF THE RAT MHC.
Technology keywords
Not reported