High-throughput Live Cell Senescence Countermeasure Screening Platform

As spacecraft shielding remains insufficient against heavy-ion space radiation, it poses a significant hazard to astronauts and presents a major barrier to mission success. The heightened risk of senescence during and following prolonged deep space missions is among the most alarming long-term effects of space radiation exposure. Implementing effective countermeasures (CMs) to target senescence has the potential to mitigate the impact of ionizing radiation (IR) exposure and ensure the well-being of astronauts during extended space missions. Because of lack of a reliable individual marker of senescence, there is an unmet need to establish a high-throughput screening platform aimed at devising a comprehensive medical countermeasure strategy to combat heavy-ion space radiation-induced senescence and protect astronauts. Lynntech proposes a novel high-throughput live cell screening platform for precise quantification and identification of senescent cells.