An Integrated Clinical Ensemble (ICE) for Autonomous Critical Care in Deep Space

The highly dynamic nature of Critical illness on deep space missions will require Astronaut crews to provide completely autonomous, Earth independent, Medical care. Critical care in an ideal well staffed and equipped Intensive Care Unit (ICU) hospital environment on Earth requires teams of expert caregivers function asnbsp;highly coordinated teams with immediate access to telemedicinenbsp;and evacuation.nbsp;Critical care in space will be delivered with extremely limited resources, by a team of non-expert caregivers led by a single crew medical officer, in a small confined space. An Integrated Clinical Ensemble (ICE) that functions as a hearing, seeing, and speaking crew member will assist crews with intensive management of these complex patients when combined with the clinical reasoning ability of an Autonomous Medical Response Agent (AMRA)AMRA is a multi-criteria feedback control Bayesian clinical decision support tool developed for NASA. AMRArsquo;s Bayesian graphsnbsp;calculate post-test likelihood of possible disease states, clinical outcomes, and mission outcomes (Medical-101).nbsp;Levels of expertise, inventory, and crew preferencesnbsp;personalizenbsp;guidance, allow calculation of Equivalent system massnbsp;resource costs (Medical-201 and medical system trade space analysis (Medical-301). AMRArsquo;s outcome graphs estimate the current and futurenbsp;multi-system state health from diagnostic and treatment data to provide an estimated risk prognosis. AMRA sends all data back to mission control and will reduce mission resource costsnbsp;(Medical-701).nbsp;The primary objective of this Phase Inbsp;is to build upon AMRA to establish the feasibility of an explainable, Integrated Clinical Ensemble (ICE) that incorporates multiple streams of input to integratenbsp;Bayesian prognostic causal network, and is therefore able to explain and coordinatenbsp;the simultaneous collaborative delivery of Critical Care with multiple human crew mates both on Earth and in Space as annbsp;integrated exploration medical system (Medical-501)