Rapid Infection Screening via Exhalation (RISE): A Breathalyzer Platform for Early Detection of Viral Respiratory Infection

N5 Sensors proposed to develop a non-thermal screening device to enable real-time breath analysis for viral infection in non-clinical settings. The approach is based on the use of N5’s chip-scale chemical sensors configured into a low-cost, portable system. The concept, Rapid Infection Screening via Exhalation (RISE) will distinguish different respiratory pathogens including those of viral or bacterial origin. In Phase I N5 developed a foundation for future development work by identifying key biomarkers of viral infection, developing prototype concepts, and conducting a market analysis of current and developmental approaches.The Phase I work provides a solid foundation for the Phase II design and prototyping effort.The RISE sensing device is based on detection of volatile organic compound (VOC) chemical signatures in breath samples, in real time, using N5’s sensor array technology platform. In Phase II the sensor technology will be proven out in laboratory studies; RISE design concepts will be further developed; and a prototype will be fabricated for further testing. At the conclusion of the Phase II a RISE prototype will be tested with human breath samples to provide initial validation of the approach. Phase II completion will lead to performance and design documentation suitable for technology transition. Ultimately RISE will provide a unique capability for rapid screening of viral infections in public areas, such as airports. RISE would enable airports to have a higher degree of screening without using more time-consuming and expensive analytical tests.