UltraFISH+ for Single-cell Spatial Cell Type Analysis

SBIR AbstractSingle cell biology is a multi-disciplinary study to investigate how large number of single cells interact with each other as a complex system. In the Cell Atlas Era, identifying cell types with high spatial resolution and accuracy is essential to decipher tissue heterogeneity and understand the biological systems profoundly, and ultimately promote the development of next generation clinical diagnostics and personalized medicine. However, existing technologies for spatial cell type analysis have various technical limitations and can’t quantify tissue heterogeneity at single cell level accurately and efficiently. UltraFISH+ is aiming to overcome the limitations of existing single cell analysis technologies and become the best tool for spatial cell type analysis. With the successful development of UltraFISH+, tissue heterogeneity will be quantified accurately, efficiently and cost-effectively.SBIR Project Narrative Project Narrative: UltraFISH+ is a technology that will enable researchers to profile spatial cell types from thousands to millions of cells in an accurate, efficient and cost-effective way. In the Cell Atlas Era, UltraFISH+ will become an essential tool for a very broad range of biologists and medical doctors across academia, biotech industry and clinical labs. It will help answer fundamental questions in all aspects of biology, as well as support the in-depth cell type mapping of primary tissues to diagnose diseases fast and accurately.