SBIR/STTR Research Award
Identification of Cell Type-specific EVs for Neuroscience Research
Award amount
$1,443,089Program and phase
SBIR · Phase IIAward year
2019Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- National Institutes of Health
- Recipient company
- Cellarcus Biosciences, Inc.
- Proposal award date
- 2019-04-15
- Contract end date
- 2021-03-31
- UEI
- QUVQAKJFJCQ9
- Solicitation number
- PA18-574
- Topic code
- NIDA
Research abstract
Abstract
All cells in the body, including brain cells, release small vesicles that can be found in blood,
cerebrospinal fluid, and even urine. Because each vesicle was released by a specific cell, their
analysis can tell us about the cells from which they came, including whether that cell was
infected, cancerous, or malfunctioning in some way. We will produce tools to analyze these
vesicles to improve the ability to detect, treat, and prevent disease.Narrative
To meet the needs of neuroscientists investigating the role of extracellular vesicles in normal
neurophysiology and disease, we will develop and validate assay kits that enable the high
resolution measurement of EV number, size, and surface cargo directly in biofluids such as
cerebrospinal fluid and blood.
Technology keywords
Not reported
Other awards by this recipient
Verified by the same UEI. These are other public SBIR/STTR award pages, not a merged company record.
- Quantitative Analysis of Cancer-associated EVs
- Assays and kits for MSC-derived extracellular vesicles
Awards with the same topic code
Verified by an exact topic code match. This is not a text-similarity match.
- Wearable Wireless Respiratory Monitoring System that Detects and Predicts Opioid Induced Respiratory Depression
- Building and testing the Life Enhancement and Advocacy Programming digital training tool (LEAPLink) to better serve people with lived experience of homelessness and substance use disorder
- A digital intervention to decrease self-stigma among pregnant and postpartum women with opioid use disorder
- Development of medication for the treatment of respiratory depression due to opioid (prescribed or illicit) overdose/multidrug (polysubstance) overdose in a hospital or community setting.
- Creation and Validation of the Dose-Opioid-Source Evaluation tool (DOSE) - a Robust Opioid Use Clinical Outcome Assessment for Qualification as an FDA Medical Device Development Tool (MDDT)
Research funding history
3 SBIR/STTR records share this UEI (2019–2023). Reported award amounts total $5,089,417. Reported amounts are not federal obligations.
Phases: Phase II, Phase II – Direct to Phase II
Agencies: Department of Health and Human Services