Antimicrobial dermal matrices to promote infection free wound closure in cutaneous wounds

OverviewThis Fast track project aims to test the feasibility of a self assembly peptide hydrogel for the treatment of woundsWound care is currently an expensivemultistep process in which wounds are treated with sequential products toremove pathogens with antibioticspromote a healthy cellular environment through hydrogel applicationandclose the wound with skin substitutesThusthe proposed product G Derm is capable of simultaneously removing drug resistant pathogens through biophysical disruption of bacterial membraneswhile promoting host tissue regeneration without added antibiotics or biologicsThis product can be used in inpatient and outpatient wound care clinics to heal patients infected with drug resistant bacteriaand to reduce theamputations performed each year in the US due to chronic woundsKey wordstissue regenerationinfectionswound healingbiomaterialsantimicrobial Areas of applicationtissue regeneration and repairwound healinginfections Subtopic nameBiomedicalBMTechnologies Intellectual MeritThis Fast track proposal will generatekenabling data demonstrating safety and efficacy of G Derm as an antimicrobial cell scaffolding matrix that is simultaneously toxic to antibioticresistant bacterial strainswhile remaining conducive to tissue regenerationThe current product uses a charge based mechanism to lyse bacterial membranes upon contact and has a porous structure to promote cellular infiltration and cell attachmentBroader ImpactThe broader impact of this Fast track proposal would be the development of a novel antimicrobial mechanism that can eliminate even drug resistant bacterial strains from infected woundsAccording to the Centers for Disease Control and Prevention Reportantibiotic resistant bacteria will cause serious infections inmillion Americans each yearresulting in an estimateddeaths annuallyOur ability to fight antibiotic resistant bacteria is diminishingand the pipeline of new potential antibiotic drugs is growing leanOnlynew antibiotics have received FDA approval sinceof which onlyof these incorporated novel mechanisms of actionHencethe proposed product offers the unprecedented combination of simultaneous bacterial elimination while promoting tisue regenerationAs the antibacterial mechanism is biophysicalbacteria are unlikely to develop resistance to this product Project Narrative The proposed product G Derm is a flowableantimicrobial skin scaffolding matrix that promotes infection free healing of woundsThis product is designed to incorporate three major benefits in a single materialibroad spectrum antimicrobial activityiitissue scaffolding matrixand iiiflowable properties to fill wounds of any sizeshape and depthThis product is easy to apply and has the potential to mitigatemillion infections anddeaths associated with poor wound closure and antibiotic annually