Field-Usable Designer Drug Analyzer

While this solicitation describes the need for better sampling methods and more rugged mass spectrometers to meet this DoD requirement, the topic author agreed to consider our alternative approach, which employs existing DoD Raman spectrometers. The goal of this proposed project (through Phase III) is to develop a Field-Usable Designer Drug Analyzer capable of identifying and quantifying drugs in saliva and blood at 10 ng/mL in 10 minutes. Feasibility will be demonstrated during Phase I by developing a novel sample system that separates drugs from saliva and blood for analysis by Raman spectroscopy. The analyzer detection limits and measurement time will be quantified by measuring aspirin, codeine and fentanyl in both saliva and blood samples. The goal of the Phase II project is to design and build a sample cartridge and interface that attaches to existing DoD Mil-Std 810G hand-held Raman spectrometers. It will be used to measure ~50 drugs in saliva and blood. The analyzer and cartridge will be validated by comparing measurements of real saliva and blood samples containing highly potent drugs, such as fentanyl and synthetic cannabinoids, with clinical laboratory measurements performed through an existing partnership with Yale University and the local Veterans Affairs Medical Center.