SBIR/STTR Research Award

Highly Scalable Multiplexed CRISPR Technologies for Medical, Industrial, and Agricultural Applications

Award identifier e0b64455e267f6caa24185be48c32c434301ef41461dbe0f50fb6810bc1ff957Awarding agency Department of Defense · Defense Advanced Research Projects Agency

Award amount

$1,459,755

Program and phase

SBIR · Phase II

Award year

2018

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Award details

Awarding agency
Department of Defense
Branch
Defense Advanced Research Projects Agency
Recipient company
De Novo DNA
Proposal award date
2018-09-18
Contract end date
2020-10-17
UEI
FQUMSWDTHE29
Solicitation number
16.3
Topic code
SB163-003

Research abstract

We propose to create transformative technologies to overcome several CRISPR-wide challenges that will broadly enable scalable, multiplexable gene editing & gene regulation with minimal off-target activity. Our technical solutions combine computational design of optimal CRISPR components, genetic circuits, and RNPs together with experimental validation. We will implement several demonstrative applications to exemplify how these technologies fundamentally transform CRISPR from a 1-guide, 1-unique site tool to a many-guide, many-gene platform with many thousands of potential industrial, medical, and agricultural applications.

Technology keywords

Not reported

Other awards by this recipient

Verified by the same UEI. These are other public SBIR/STTR award pages, not a merged company record.

Agency intelligence

Department of Defense

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