Limited Competition: Biospecimen Banks to support NCI National Clinical Trials Network Biospecimen Banks (NCTN Biobanks) and the NCI Early-Phase and Experimental Clinical Trials Biospecimen Bank (EET Biobank) (U24 Clinical Trial Not Allowed)

Opportunity details

Agency

National Institutes of Health

Notice type

Federal Grant

Original posted

October 15, 2026

Last updated

October 18, 2026

Notice ID

grant-361134

Summary

This is a Notice of Funding Opportunity (NOFO) for a Limited Competition that will invite application(s) from eligible organization(s) to apply. Please see Section III. Eligibility for additional information. In accordance with NIH standard peer-review processes, the application(s) will be peer-reviewed, and only meritorious application(s) will be considered for funding. Through this limited competition Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) solicits applications to support continuation of two biospecimen banking resources.The National Clinical Trials Network (NCTN) Biospecimen Banks (NCTN Biobanks) support the NCI-funded NCTN and the Community Oncology Research Program (NCORP), and The Early-Phase and Experimental Clinical Trials Biospecimen Bank (EET Biobank) supports the Experimental Therapeutics Clinical Trials Network (ETCTN) and other NCI-supported early phase and experimental clinical trials.The objective is to maintain these national resources for the collection, processing, storage, and distribution of high-quality, clinically annotated human biospecimens. The goal of these resources is to ensure the availability of biospecimens from participants in NCI-funded clinical trials focused on treatment, prevention, and cancer control studies to enable translational cancer research. The NCTN Biobanks support biomarker development and validation, secondary correlative studies, and broader scientific discovery using biospecimens collected through harmonized protocols and linked to clinical outcome data from large multi-site clinical trials.The EET Biobank supports biospecimen banking for ETCTN and other early-phase and experimental therapeutic clinical trials involving investigational agents. Biospecimens collected through these studies support biomarker assay development, pharmacokinetic and pharmacodynamic analyses, investigation of drug response and resistance mechanisms, patient stratification, and translational research supporting development of novel cancer therapies. In accordance with NIH standard peer-review processes, the application(s) will be peer-reviewed, and only meritorious application(s) will be considered for funding.

Summary fields are from official SAM.gov or Grants.gov structured data. CaptureIQ does not republish full solicitation or grant text.

Eligibility

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Eligibility is limited to an institution/entity that is the recipient of an existing NCTN biobank of human biospecimens from NCI clinical trials funded under RFA-CA-20-002 or an existing EET Biobank of human specimens under RFA-CA-20-003.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Eligibility is limited to an institution/entity that is the recipient of an existing NCTN biobank of human biospecimens from NCI clinical trials funded under RFA-CA-20-002 or an existing EET Biobank of human specimens under RFA-CA-20-003.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Eligible applicant categories

• Others (see text field entitled "Additional Information on Eligibility" for clarification)

Official Grants.gov eligibility information. Listed categories are not a determination that an organization qualifies.

Funding and program

Assistance Listing

93.394

Funding instrument

CA

Cost sharing

Not required

Estimated total program funding

$19,000,000

Expected number of awards

6 (government estimate, not a guaranteed count)

Official modification date

October 15, 2026

Estimated total program funding is the government figure for the whole program, not an individual award ceiling. The expected number of awards is a government estimate, not a guaranteed count. These figures are estimates, not guaranteed funding.

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