NIH Director’s Transformative Research Award for Individual and Group Science (R01 Clinical Trial Optional)

Opportunity details

Agency

National Institutes of Health

Notice type

Federal Grant

Original posted

June 29, 2026

Last updated

August 30, 2026

Notice ID

grant-361084

Summary

The NIH Director"s Transformative Research Award supports individual scientists or groups of scientists proposing bold, groundbreaking, exceptionally innovative, original, and/or unconventional research with the potential to create new scientific paradigms, establish entirely new and improved clinical approaches, or develop transformative technologies. Applications in any area within the biomedical sciences are welcome; topics may involve basic, translational, or clinical research. No preliminary data are required. Projects must clearly demonstrate, based on the strength of the logic, a compelling potential to produce a major impact in a broad area of relevance to the NIH. The NIH Director"s Transformative Research Award is a component of the High-Risk, High-Reward Research (HRHR) program of the NIH Common Fund.

Summary fields are from official SAM.gov or Grants.gov structured data. CaptureIQ does not republish full solicitation or grant text.

Eligibility

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Eligible applicant categories

• Private institutions of higher education
• Special district governments
• Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
• Native American tribal organizations (other than Federally recognized tribal governments)
• State governments
• County governments
• City or township governments
• Small businesses
• Independent school districts
• For profit organizations other than small businesses
• Public housing authorities/Indian housing authorities
• Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
• Native American tribal governments (Federally recognized)
• Public and State controlled institutions of higher education
• Others (see text field entitled "Additional Information on Eligibility" for clarification)

Official Grants.gov eligibility information. Listed categories are not a determination that an organization qualifies.

Funding and program

Assistance Listing

93.310

Funding instrument

Grant

Cost sharing

Not required

Estimated total program funding

8,000,000

Expected number of awards

7 (government estimate, not a guaranteed count)

Official modification date

June 29, 2026

Estimated total program funding is the government figure for the whole program, not an individual award ceiling. The expected number of awards is a government estimate, not a guaranteed count. These figures are estimates, not guaranteed funding.

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