Multimodal microscope for intraoperative assessment of breast surgical margins

Project Summary AbstractPhysical SciencesIncPSIin collaboration with MD Anderson Cancer CenterMDACCand Caliber IDRochesterNY proposes to develop a novel technology for real time assessment of surgical margins on breast cancer lumpectomy specimens and provide immediate feedback to the surgeonA multimodal microscope will be used in conjunction with a high sensitivity cancer targeting agent to detect positive margins on lumpectomy specimensEnhanced contrast fluorescence imaging will be first applied to identify potentially positive marginswhile combined high resolution confocal microscopy optical coherence tomography imaging will be then used to visualize tissue morphology at the sub cellular scale and confirm or rule out cancer presenceIn Phase I we demonstrated the suitability of this technology for positive cancer margins detection on surgical specimens in a benchtop studyBased on Phase I observations and conclusions we propose to further improve this technology in Phase II and perform a larger scale clinical validation study at the MD Anderson Cancer CenterHoustonTXFurthermorea commercialization strategy for this technology will be developed and preliminary steps towards reaching this goal will be taken