An Automated RNA 3D Structure Determination System

DESCRIPTION provided by applicant The central dogma of molecular biology has undergone a significant revision where RNAs have emerged as important regulators of cell activity Astonishingly as much as of human DNA is transcribed into RNA as recently reported by the Encyclopedia of DNA Elements ENCODE consortium New classes of RNA are being identified including many which are non protein coding ncRNA Nonetheless ncRNAs are involved in regulating cellular activity Deciphering the structure function relationship of these RNAs is of immediate importance as ncRNAs have now been implicated in a variety of diseases including myotonic dystrophy type prostate cancer spinal muscular atrophy and Huntingtonandapos s disease like Traditional approaches to determine high resolution RNA D structures have proven to be prohibitively time consuming and expensive Nymirum has developed an Automated RNA D Structure Determination System that is faster cheaper and more robust than current approaches This System will be commercialized for use by the drug industry and academic researchers in their quest to understand and treat human disease PUBLIC HEALTH RELEVANCE RNA D structure and function information is critical to understanding basic cell function delineating dysfunctional RNA contribution to human disease and finding new drugs to treat diseases caused by dysfunctional RNAs Nymirum has developed an Automated RNA D Structure Determination System that is faster cheaper and more robust than current approaches