SBIR/STTR Research Award
An Automated RNA 3D Structure Determination System
Award amount
$215,024Program and phase
SBIR · Phase IAward year
2014Award details
- Awarding agency
- Department of Health and Human Services
- Branch
- National Institutes of Health
- Recipient company
- Nymirum, Inc.
- Proposal award date
- Not reported
- Contract end date
- Not reported
- UEI
- ZJRRLDJNHJC9
- Solicitation number
- PA13-234
- Topic code
- NIGMS
Research abstract
DESCRIPTION (provided by applicant): The central dogma of molecular biology has undergone a significant revision where RNAs have emerged as important regulators of cell activity. Astonishingly, as much as 80% of human DNA is transcribed into RNA as recently reported by the Encyclopedia of DNA Elements (ENCODE) consortium. New classes of RNA are being identified including many which are non-protein coding (ncRNA). Nonetheless ncRNAs are involved in regulating cellular activity. Deciphering the structure-function relationship of these RNAs is of immediate importance as ncRNAs have now been implicated in a variety of diseases including myotonic dystrophy type 1, prostate cancer, spinal muscular atrophy, and Huntington's disease-like 2. Traditional approaches todetermine high-resolution RNA 3D structures have proven to be prohibitively time consuming and expensive. Nymirum has developed an Automated RNA 3D Structure Determination System that is faster, cheaper, and more robust than current approaches. This
Technology keywords
Not reported
Other awards by this recipient
Verified by the same UEI. These are other public SBIR/STTR award pages, not a merged company record.
- Developing Drug-like Small Molecules that Target Toxic Repeat RNAs to Alleviate Myotonic Dystrophy Type 1-derived Mis-Splicing
- Targeting Exonuclease Resistant RNA to Develop Zika Virus Therapeutics
- A Small Molecule Drug Discovery Platform to Target Cancer Causing microRNAs
- An Automated RNA 3D Structure Determination System
- Modular Ultrasonic Beacon System (MUBS) for Ultrasound-guided Interventional Surg
Awards with the same topic code
Verified by an exact topic code match. This is not a text-similarity match.
- Three-Dimensional Spatio-Temporal Control of Lipid Nanoparticle Manufacturing for Improved Nucleic Acid Delivery
- Paradigm-changing, versatile, scalable and cost-effective technology for monthly injections of peptide drugs
- Project MATCH: Multi-spectral AI/ML powered Burn and Wound Evaluation Technology using a Cost-Effective Handheld Device.
- A versatile platform to isolate cells from three-dimensional samples after spatial and temporal profiling
- Development of an Educational Product for Accelerating Solutions for Commercialization and Entrepreneurial Development (ASCEND) in Western IDeA States
Research funding history
6 SBIR/STTR records share this UEI (2013–2020). Reported award amounts total $2,813,579. Reported amounts are not federal obligations.
Phases: Phase I, Phase II
Agencies: Department of Health and Human Services