Enhancing engraftment of cord blood for treatment of neoplastic disorders

DESCRIPTION provided by applicant Hematopoietic stem cell transplantation is a form of stem cell therapy used to treat cancers such as lymphoma and leukemia and other blood related diseases However there currently are several drawbacks in the use of bone marrow hematopoietic cell transplantation Most importantly the donor pool is limited by the need for at least partial HLA matching and this delays the finding of a suitable donor Human umbilical cord blood hUCB is increasingly being used as an alternative source of HSC HPC cells for allogeneic HSCT However the absolute number of hUCB HSCs transplanted is much lower than bone marrow cells and results in significantly delayed engraftment The proposed studies are to test the efficacy and safety of TAT SALL in reducing the number of hUCB HSCs required for short and long term engraftments following irradiation through expansion of HSCs HPCs in vivo One of main goals in this proposal is to develop a safe strategy of using a TAT SALL protein for hematopoietic stem cell therapies Most importantly our work would greatly impact the field with improved patient outcomes broader patient usage and possibly lead to the use of just a single umbilical cord for transplantation of HSCs in adults suffering fro acute radiation syndrome lymphoma leukemia or other blood related diseases PUBLIC HEALTH RELEVANCE Our main goals in this proposal are to develop a safe strategy of using a TAT SALL protein for hematopoietic stem cell therapy Most importantly our work would greatly impact the field with improved patient outcomes broader patient usage and possibly lead to the use of just a single cord for transplantation of HSCs in adults suffering from acute radiation syndrome lymphoma leukemia or other blood related diseases