Microfluidic-based device for ambient mass analysis

This project (technology transfer opportunity) is aimed at significant improving both the efficiency and performance of the ambient pressure nanoDESI ionization source for the comprehensive analysis of aerosol particles and surfaces including biological tissues by tandem mass spectrometry (MS/MS). Broad applicability of nanoDESI-based MS analysis makes it a unique analytical tool specifically targeting trace amounts of many chemical and biological substances. During implementation of this project we plan to develop and test a microfluidic chip and a novel subatmospheric ionization source which significantly improves efficiency and stability of the nanoDESI technique. The overall objective of this project is to build a robust commercial device facilitating mass analysis of aerosol and biological samples. The development of stable ionization and sample delivery techniques is the aim of Phase I. To facilitate operation of the device, the nanoDESI platform to be built will be made of two halves. One half will be integrated with an interface mounted on the inlet of mass spectrometer, while another half will be mounted on a XY stage holding the sample under analysis. Liquid connection between the halves will be provided by short piece of flexible capillary. Commercial applications include molecular-based aerosol analysis and analysis of biological tissues