SBIR/STTR Research Award
PNA-Based Rapidly Adaptable Anti-Microbial Nanoparticles
Award amount
$100,000Program and phase
SBIR · Phase IAward year
2012Award details
- Awarding agency
- Department of Defense
- Branch
- Defense Advanced Research Projects Agency
- Recipient company
- AGAVE BIOSYSTEMS INC.
- Proposal award date
- 2012-07-19
- Contract end date
- 2013-07-31
- UEI
- SDSPMQR27BH4
- Solicitation number
- 2012.1
- Topic code
- SB121-003
Research abstract
Agave BioSystems proposed to develop a system of Rapidly Adaptable Nanotherapeutics (RANT) by combining advanced bioformatics, with DNA-based nanoparticles, peptide nucleic acid (PNA) antisense oligonucleotides, and cell permeating peptides (CPPs). Advanced bioinformatics computing will allow for the identification of essential and drug resistance genes within the target pathogens. These genes will be used to develop and synthesize PNA based anti-sense oligonucleotides. These PNAs are designed to suppress the growth and destroy the target microorganisms. DNA nanoparticles coated with CPPs will be used to get the anti-sense PNAs into the target microorganisms. Combined, these components will allow for the rapid targeting of essential or drug resistance microbial genes, and the delivery of stable antisense oligonucleotides into the target microorganisms.
Technology keywords
Not reported
Other awards by this recipient
Verified by the same UEI. These are other public SBIR/STTR award pages, not a merged company record.
- Novel Screen Approach to Inactivate Whole Viral Vaccines by Supralethal Irradiation
- Identification of Patients with Clostridium Difficile Infection, Colonization and/or Reoccurrence
- Intracellular Detection of Small Molecules in Live Cells
- Multiplex Immunoassays in the Development of Vaccines Against Enteric Pathogens
- Screens for Novel Agonists/Antagonists of Endocrine Fibroblast Growth Factors
Awards with the same topic code
Verified by an exact topic code match. This is not a text-similarity match.
- Genetically Programmable Spherical Nucleic Acids as Rapidly Adaptable Nanotherapeutics
- PNA-Based Rapidly Adaptable Anti-Microbial Nanoparticles
- Rapidly Adaptable Nanotherapeutics
- Genetically Programmable Spherical Nucleic Acids as Rapidly Adaptable Nanotherapeutics
- Rapidly Adaptable Nanotherapeutics
Research funding history
102 SBIR/STTR records share this UEI (1998–2015). Reported award amounts total $29,837,745. Reported amounts are not federal obligations.
Phases: Phase I, Phase II
Agencies: Department of Defense, Department of Health and Human Services, National Aeronautics and Space Administration, Environmental Protection Agency